High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine
نویسندگان
چکیده
Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmental challenges (for example, hypobaric hypoxia, hyperbaria, microgravity, cold, heat) may be similar to responses seen in critical illness. The present review explores the idea that human responses to the hypoxia of high altitude may be used as a means of exploring elements of the pathophysiology of critical illness.
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ورودعنوان ژورنال:
- Critical Care
دوره 11 شماره
صفحات -
تاریخ انتشار 2007